In 2009, PacBio published a paper expanding the principle into a full-blown sequencing technique. Once again, each nucleotide was labeled with a different colored fluorophore detectable by the ZMW to determine which base had been incorporated. The fluorophores were attached such that they would be cleaved off during the chemical reaction incorporating the base into the growing DNA strand; they would then diffuse out of the ZMW so that the next fluorophore could be detected. Sequencing took place on a chip with many wells simultaneously — a different type of parallelization where each well detected a single DNA molecule undergoing the same basic chemical reaction.
山西省委党的建设工作领导小组召开会议，审议通过关于在全省开展学习教育的实施方案，要求各级党委（党组）扛起主体责任，主要负责同志要担负起第一责任人责任，领导班子成员要履行好“一岗双责”，充分发挥行业系统主管部门党委（党组）对本行业本系统学习教育的指导作用，精心谋划部署，认真组织实施。
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